Management faculty of Shahid Sattari Aeronautical University Innovation Management in Defensive Organizations 2676-7112 6 2 2023 06 22 The role of human resource management system and strategies on radical innovation of knowledge-based companies by explaining the mediating role of entrepreneurial orientation The role of human resource management system and strategies on radical innovation of knowledge-based companies by explaining the mediating role of entrepreneurial orientation 29 48 170031 10.22034/qjimdo.2023.387198.1568 FA Samad Barani 2. Assistant Prof., Department of Management, Shahid Sattari Aeronautical University, Tehran, Iran. 0000-0002-6677-2244 Hormat Asghari Assistant Professor, Department of Public Administration, Faculty of Management and Economics, Science and Research Branch, Islamic Azad University; Tehran, Iran. 0000-0003-0848-9624 Aref Ashrafzadeh MSc., Department of MBA, Faculty of Management, Kharazmi University, Tehran, Iran 0009-0009-6553-8497 Journal Article 2023 02 24 Background & Purpose: Innovation and human capital have been proposed as the key success factors of companies in order to achieve a sustainable competitive advantage. Therefore, this research examines the effect of strategic human resource management and human resource management system on radical innovation by considering the mediating role of entrepreneurial orientation.<br />Methodology: The current research is applied in terms of its purpose and descriptive-correlation in terms of its method. The statistical population of the research included managers of 4108 knowledge-based companies active in Tehran province. The sample size was determined by Morgan's table of 351 people. The data was collected with a standard questionnaire and by available sampling method and analyzed with PLS 3 Smart software.<br />Findings: The findings showed that strategic human resource management and human resource management system directly and indirectly (through entrepreneurial orientation) have a positive and significant effect on radical innovation. Also, the direct effect of entrepreneurial orientation on radical innovation and the direct effect of strategic human resource management and human resource management system on entrepreneurial orientation were confirmed.<br />Conclusion: Managers of knowledge-based companies by applying appropriate strategies and efficient use of human resources management system can stimulate and strengthen entrepreneurial actions and behaviors in the company, and in this way, by creating an innovative approach, achieve Facilitate competitive advantage for your company. Background & Purpose: Innovation and human capital have been proposed as the key success factors of companies in order to achieve a sustainable competitive advantage. Therefore, this research examines the effect of strategic human resource management and human resource management system on radical innovation by considering the mediating role of entrepreneurial orientation.<br />Methodology: The current research is applied in terms of its purpose and descriptive-correlation in terms of its method. The statistical population of the research included managers of 4108 knowledge-based companies active in Tehran province. The sample size was determined by Morgan's table of 351 people. The data was collected with a standard questionnaire and by available sampling method and analyzed with PLS 3 Smart software.<br />Findings: The findings showed that strategic human resource management and human resource management system directly and indirectly (through entrepreneurial orientation) have a positive and significant effect on radical innovation. Also, the direct effect of entrepreneurial orientation on radical innovation and the direct effect of strategic human resource management and human resource management system on entrepreneurial orientation were confirmed.<br />Conclusion: Managers of knowledge-based companies by applying appropriate strategies and efficient use of human resources management system can stimulate and strengthen entrepreneurial actions and behaviors in the company, and in this way, by creating an innovative approach, achieve Facilitate competitive advantage for your company. https://www.qjimdo.ir/article_170031_b3bfbe58f00b7c926c99e3e6b0de0725.pdf